{"id":3689,"date":"2022-09-08T16:00:26","date_gmt":"2022-09-08T14:00:26","guid":{"rendered":"http:\/\/cytomorpholab.com\/?page_id=3689"},"modified":"2022-09-08T16:42:26","modified_gmt":"2022-09-08T14:42:26","slug":"erc-iceberg","status":"publish","type":"page","link":"http:\/\/cytomorpholab.com\/index.php\/erc-iceberg\/","title":{"rendered":"ERC Consolidator to Manuel"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3689\" class=\"elementor elementor-3689\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-77f0e13 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"77f0e13\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-468ea0f\" data-id=\"468ea0f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2cc5ed8 elementor-widget elementor-widget-text-editor\" data-id=\"2cc5ed8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ee7d1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ee7d1f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-23d12be\" data-id=\"23d12be\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c6d8c9 elementor-widget elementor-widget-image\" data-id=\"7c6d8c9\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" width=\"603\" height=\"456\" src=\"http:\/\/cytomorpholab.com\/wp-content\/uploads\/2021\/10\/LOGO-ERC-black.jpg\" class=\"attachment-large size-large wp-image-3676\" alt=\"\" srcset=\"http:\/\/cytomorpholab.com\/wp-content\/uploads\/2021\/10\/LOGO-ERC-black.jpg 603w, http:\/\/cytomorpholab.com\/wp-content\/uploads\/2021\/10\/LOGO-ERC-black-300x227.jpg 300w\" sizes=\"(max-width: 603px) 100vw, 603px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-fcf5a18\" data-id=\"fcf5a18\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cb32f46 elementor-widget elementor-widget-text-editor\" data-id=\"cb32f46\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2>European Research Council<\/h2>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-80c6532 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"80c6532\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d096c24\" data-id=\"d096c24\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fc8da61 elementor-widget elementor-widget-text-editor\" data-id=\"fc8da61\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>ERC Consolidator Grant to Manuel Th\u00e9ry (2017 \u2013 2022)<\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e719577 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e719577\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6613702\" data-id=\"6613702\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-47c1463 elementor-widget elementor-widget-text-editor\" data-id=\"47c1463\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>Iceberg &#8211; Exploration below the tip of the microtubule<\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-83747a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"83747a6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8f1c304\" data-id=\"8f1c304\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19bb113 elementor-widget elementor-widget-image\" data-id=\"19bb113\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"800\" height=\"466\" src=\"http:\/\/cytomorpholab.com\/wp-content\/uploads\/2022\/09\/ERC-Schema-1.jpg\" class=\"attachment-large size-large wp-image-3427\" alt=\"\" srcset=\"http:\/\/cytomorpholab.com\/wp-content\/uploads\/2022\/09\/ERC-Schema-1.jpg 1000w, http:\/\/cytomorpholab.com\/wp-content\/uploads\/2022\/09\/ERC-Schema-1-300x175.jpg 300w, http:\/\/cytomorpholab.com\/wp-content\/uploads\/2022\/09\/ERC-Schema-1-768x448.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ca80a83 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca80a83\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7a2bc5c\" data-id=\"7a2bc5c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-63b8d4d elementor-widget elementor-widget-text-editor\" data-id=\"63b8d4d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Microtubules (MTs) are dynamic cytoskeleton filaments. They permanently transit between growth and shrinkage. This famous \u201cdynamic instability\u201d is governed by the addition and loss of tubulin dimers at their tips. In contrast to the tip, the MT lattice was considered to be a passive structure supporting intracellular transport. However, we recently found that MT lattice is dynamic and active! Actually, tubulin dimers can be exchanged with the cytoplasmic pool along the entire length of the MT. These incorporations can repair sites on the lattice that have been mechanically damaged. These repair sites protect the MTs from depolymerisation and increase the MT\u2019s life span. This discovery opens up a new vista for understanding MT biology. First, we will investigate the biochemical consequences of MT-lattice turnover. We hypothesise that tubulin turnover affects the recruitment of MAPs, motors and tubulin-modifying enzymes. These recruitments may feedback on lattice turnover and further regulate MT life span and functions. Second, we will investigate the mechanical impact of the MT-lattice plasticity. Tubulin removal is likely to be associated with a local reduction of MT stiffness that can impact MT shape and the propagation of forces along the lattice. We anticipate that such effects will require us to reformulate the biophysical rules directing network architecture. To achieve this, we will use reconstituted MT networks in vitro to investigate the molecular mechanism regulating MT-lattice plasticity, and cultured cells to test the physiological relevance of these mechanisms. In both approaches, microfabricated devices will be used to control the spatial boundary conditions directing MT self-organisation. By exploring the hidden 90% of MT iceberg we aim to show that the MT lattice is a dynamic mechano-sensory structure which regulates interphase MT-network architectures and possibly confers them unexpected functions.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>European Research Council ERC Consolidator Grant to Manuel Th\u00e9ry (2017 \u2013 2022) Iceberg &#8211; Exploration below the tip of the microtubule Microtubules (MTs) are dynamic cytoskeleton filaments. They permanently transit between growth and shrinkage. This famous \u201cdynamic instability\u201d is governed by the addition and loss of tubulin dimers at their tips. In contrast to the [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/pages\/3689"}],"collection":[{"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/comments?post=3689"}],"version-history":[{"count":10,"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/pages\/3689\/revisions"}],"predecessor-version":[{"id":3746,"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/pages\/3689\/revisions\/3746"}],"wp:attachment":[{"href":"http:\/\/cytomorpholab.com\/index.php\/wp-json\/wp\/v2\/media?parent=3689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}